Metastasis — the spread of cancer from one part of the body to others — accounts for more than 90 percent of cancer-related deaths. Although the cells that seed metastasis and the sites they tend to travel to have been increasingly studied over the years, little has been known about how cancer migrates from a primary site, such as breast tissue, to a secondary site, such as the brain or bone marrow.A study by researchers from Harvard-affiliated Brigham and Women’s Hospital (BWH), published in Nature Communications, offers a new view of how cancer cells extend their reach, co-opting and transforming normal cells through “metastatic hijacking.” The researchers also find that in preclinical models, pharmacological intervention can stop the hijack before it starts, pointing to new therapeutic targets for preventing cancer cells from spreading.“Metastasis remains a final frontier in the search for a cure for cancer,” said Shiladitya Sengupta of BWH’s Bioengineering Division in the Department of Medicine and corresponding author of the study. “For the past five years we have studied how cancer travels to other parts of the body, and what we find is that communication is key.”“By working together, our labs have been able to gain greater insights into cell-cell communication in tumor states, which will shed new light on cancer as a disease and the promise and potential of emerging innovative therapies,” said Elazer Edelman of BWH’s Cardiovascular Division in the Department of Medicine.Sengupta, Edelman, and colleagues began with a simple experiment. In the lab, they constructed a 3-D tumor matrix, complete with endothelial cells, and added metastatic breast cancer cells. They observed that instead of adhering together to form a sphere, the metastatic breast cancer cells spread out along the model’s blood vessels. Using a scanning electron microscope, the researchers detected long, thin tubes extending outward from the cells — nanoscale bridges that connected the cancer cells to normal tissue. The researchers found that the molecular profiles of some of the normal endothelial cells had been changed, and hypothesized that microRNAs were being transferred over the bridges into the endothelial cells. Upon closer examination, they found that the transformed endothelial cells now harbored two microRNAs that previously had been implicated in metastasis.The researchers then used chemical compounds to prevent the nanoscale bridges from forming, disrupting communication between the tumor cells and endothelium. They did so in the laboratory-constructed model and also in a mouse model, finding that pharmacological agents, including docetaxel, which is used to treat metastatic breast cancer, decreased the number of nanoscale bridges the cells formed. In mice pretreated with the pharmacological agents, the researchers observed a significant decrease in metastatic tumor burden.In future studies, the researchers will look to see if ATPase inhibitors — drugs that have been studied for treating HIV-AIDS — may also be able to inhibit metastasis by preventing the bridges from forming.“Our study opens up new avenues for exploration and suggests that these nanoscale membrane bridges may represent new therapeutics in managing metastatic breast cancer,” said Sengupta, who is an assistant professor of medicine at Harvard Medical School. “We plan to continue searching for and evaluating treatments that take aim at these conduits.”Other researchers who contributed to this work include Yamicia Connor, Sarah Tekleab, Shyama Nandakumar, Cherelle Walls, Yonatan Tekleab, Amjad Husain, Or Gadish, Venkata Sabbisetti, Shelley Kaushik, Seema Sehrawat, Ashish Kulkarni, Harold Dvorak and Bruce Zetter. This work was supported by the National Institutes of Health, a Department of Defense Breast Cancer Research Program Breakthrough Award, an American Lung Association Innovator Award, and the National Institute of General Medical Sciences.
Paul, Frank & Collins, attorneys at law, is pleased to announce that Rebecca van Doren has joined the firm as an Associate. Ms. van Doren was admitted to the Vermont Bar on November 19, 2002, and will be concentrating her practice on general trial work, with a focus on intellectual property, including patent, copyright and trademark litigation, product liability, commercial litigation, and anti-trust matters.Ms. van Doren is a 1985 graduate (Dean’s List) of Arizona State University and a 1998 graduate of Arizona State University, College of Law (cum laude).Before joining Paul, Frank & Collins, Ms. van Doren worked as an Associate at Cohen, Kennedy, Dowd & Quigley, P.C. Ms. van Doren was also law clerk to the Hon. E.G. Noyes, Jr. of the Arizona Court of Appeals, and law clerk/bailiff for the Hon. Edward O. Ballinger of Maricopa County Superior Court in Phoenix, Arizona. Ms. van Doren is also admitted to the Arizona State Bar and the U.S. District Court in Arizona.Paul, Frank & Collins, is pleased to announce that Chris Leff has joined the firm as an Associate. Mr. Leff was admitted to the Vermont Bar on November 19, 2002, and will be concentrating his practice on corporate and tax law.Mr. Leff is a 1994 graduate (magna cum laude) of the University of Vermont and a 2001 graduate of the University of Minnesota Law School (magna cum laude).Before joining Paul, Frank & Collins, Mr. Leff worked in the Tax Department of Dorsey & Whitney, LLP in Minneapolis, Minnesota. Mr. Leff is also admitted to practice law in the state of Minnesota.Formed in 1968, Paul, Frank & Collins is a full-service law firm serving commercial, institutional and individual clients throughout the United States and Canada.
FacebookTwitterLinkedInEmailPrint分享The Guardian:Britain’s switch to greener energy will take another significant step forward this week with the opening of an industrial-scale battery site in Sheffield.E.ON said the facility, which is next to an existing power plant and has the equivalent capacity of half a million phone batteries, marked a milestone in its efforts to develop storage for electricity from windfarms, nuclear reactors and gas power stations.The plant, housed in four shipping containers, is the type of project hailed by the business secretary, Greg Clark, as crucial to transforming the UK’s energy system and making it greener.Centrica, the parent company of British Gas, is building a 49MW facility on the site of a former power station in Barrow-in-Furness, Cumbria, while EDF Energy is working on one of the same size at its West Burton gas power station in Nottinghamshire.David Topping, the director of business, heat and power solutions at E.ON, said: “This is a milestone for E.ON in the new energy world and an important recognition of the enormous potential for battery solutions in the UK.”The utility-scale batteries are being built in response to a request from National Grid, the owner of Britain’s power transmission network, for contracts to help it keep electricity supply and demand in balance, which is posing an increasing challenge for the grid as more intermittent wind and solar comes online.Balancing supply and demand is essential for keeping the frequency of electricity constant at 50Hz across the UK. The ability of batteries to respond to demand in less than a second makes them ideal for the task, with earlier sources of backup power much slower at just under 10 seconds.E.ON has secured £3.89m of the £65.9m of contracts awarded for the service, though National Grid estimates the batteries will save it £200m over four years.Leon Walker, the commercial development manager at National Grid, said: “Using battery storage is a significant development for managing the national grid. It’s an ultra-fast way of keeping electricity supply and demand balanced.”More: Mega-battery plant to come online in Sheffield U.K. Marks a Milestone in Industrial-Scale Grid Storage
Pearce noted that she hoped “people respect us to understand that we are humans and I certainly didn’t get married to get divorced,” adding that “things happen.”Listen to Watch With Us to hear more about your favorite shows and for the latest TV news! Us Weekly confirmed that Pearce filed for divorce from Ray in June after eight months of marriage. She made their relationship Instagram official in July 2018, and they tied the knot in October 2019.The “Hide the Wine” singer spoke out about the split in October, telling ET Canada that the biggest lesson she learned was that she is “way stronger than I thought.”- Advertisement – The “Next Girl” songstress teased the performance via Instagram on Thursday, November 5, prior to Brice’s diagnosis. “I truly have no words for this one,” she wrote. “I have dreamt of singing one of my songs on the @cma awards since I was a little girl, and it’s finally happening. Watch Country Music’s Biggest Night LIVE next Wednesday on ABC as I perform ‘I Hope You’re Happy Now’ with @leebrice! (And probably low key cry into my microphone) #cmaawards.”Although the track focuses on a couple moving on after a breakup, Pearce had someone other than Ray, 32, in mind when she penned the song. She revealed in December 2019 that she actually called it quits with her ex, whom the tune is based on, because of her feelings for the fellow country star.AFF-USA/Shutterstock“I’m married, and I don’t want anyone to think that I have this person still lingering in my past or looming because this is my story,” she explained in a YouTube video. “But I also feel like this person is in a good place too, and I wanted people to kind of, the payoff of that to be he’s finally seeing his ex-girlfriend for the first time and is able to kind of look her in the face and say, ‘It’s OK.’”- Advertisement – Singing away the pain? Carly Pearce performed a duet with Charles Kelley at the 2020 Country Music Association Awards amid her divorce from estranged husband Michael Ray.Pearce, 30, and Kelley, 39, sang her hit “I Hope You’re Happy Now” at the Wednesday, November 11, awards ceremony, which took place in Nashville. The Lady A member replaced her original duet partner, Lee Brice, after the 41-year-old crooner tested positive for coronavirus.Carly Pearce and Charles Kelley perform “I Hope You’re Happy Now” at the 2020 CMAs. John Russell/Country Music Association Inc./Shutterstock- Advertisement – – Advertisement –
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Check out the leafy outlook at 23 Cromwell Close, Brookfield.The previous highest price paid for a home at Cromwell Close was $885,000 in 2014, according to researcher CoreLogic.“The buyers are a busy couple that work in the city and wanted the peace and quiet,” Mr Juresic said.“They get that with this home which offers great privacy overlooking bushland, yet it’sonly around 13km to Brisbane’s CBD.”Located in the Kensington Estate, the home is on a 1010sq m allotment on a no-through road. More from newsDigital inspection tool proves a property boon for REA website3 Apr 2020The Camira homestead where kids roamed free28 May 2019One of the bedrooms at 23 Cromwell Close, Brookfield.Mr Juresic said the house was beautifully renovated by the sellers, who had lived there for 19 years.“They raised their children there and then realised the home was too large for just the two of them,” he said. 23 Cromwell Close, Brookfield.The lure of a peaceful escape from the city grind has resulted in the record sale of a home in Brisbane’s leafy Brookfield.The four-bedroom, two-bathroom home at 23 Cromwell Close sold for $1.020 million a few weeks ago.NGU Real Estate’s Emil Juresic sold the double-storey home within a week of listing the property.
A canal dredging work along Bang Krasan in Ayutthaya, Thailand, is nearing its completion and is set to be wrapped up by April 30, the Bangkok Post reports. The project, inspected by Deputy Prime Minister Prawit Wongsuwon yesterday, is about 98% completed.Bang Krasan is a 2.2-kilometer canal in Ayutthaya’s Bang Pa-in district that channels some of the Chao Phraya’s water to Prem Prachakorn as it flows downstream towards Bangkok – slowing the massive run-off from the North which usually hits the capital when the rain begins to pick up.The project is not only aimed at preventing floods in the capital, as it will also improve water transportation along Bang Krasan and Prem Prachakon.
LAS VEGAS, Nev. (Nov. 11) – Nothing slowed Terry Phillips on his way to a career fourth IMCA Modified Duel In The Desert victory and a $7,777 paycheck Saturday at the Las Vegas Motor Speedway Dirt Track.Phillips led all but the first of 40 laps, nearly hitting the wall getting around traffic before pulling ahead to win nearly eight seconds ahead of Eddie Belec.The race stayed green the last 36 laps. Peyton Taylor, Johnny Scott and Cody Laney rounded out the top five finishers at the 20th annual event, the biggest of the season in IMCA’s Larry Shaw Racing Western Region.“These slick tracks, I like them. I guess I’m getting a little long in the tooth, but I’ve got a lot more left in me, probably more than most of these young kids,” said Phillips, from Springfield, Mo., and also the Duel winner in 2010, 2011 and 2014. “There were a couple lanes and I was all over this thing. It was awesome.”Arvada, Colo., speedsters Belec and Dominic Ursetta made up the front row but the third starting Phillips was ahead of both by the time the second lap was scored. Belec stayed close following the early restart but lost ground when Phillips moved from the high line to the middle groove.Taylor caught Ursetta for third while Phillips gradually moved down on the track and into the same line as Belec by lap 13.Lapped cars came into play beginning at halfway. Phillips moved back to a higher groove looking for the fastest way through and came close to catching the turn four wall on lap 29.He cleared traffic and left the battle for second well behind by lap 35. The main event was completed in just 20 minutes, with Belec .19 of a second ahead of Taylor at the finish.“Somebody hit me at the end coming off the corner and I didn’t know if it was second place. I thought, ‘I better get going here!’” Phillips said, adding plugs for teammate Jordan Grabouski and his crew as well as Toby Kruse for the track prep. “With the lapped cars, sometimes you’ve got to try different lines to see if you’re faster or not. It’s kind of like playing chess: You’ve got to make the right moves.”Phillips was already a candidate for the 2018 Fast Shafts All-Star Invitational ballot. Jeremy Payne, 24th in this year’s event, leads all Modified drivers with five career Duel In The Desert crowns.Chris McKellar and Nick Spainhoward both made the trip to the Dirt Track from Bakersfield, Calif., and were separated by less than a second at the finish of the $1,777 to win Karl Chevrolet Northern SportMod main.McKellar started from the pole and led all 25 laps, beating Spainhoward, Robert Elliott, 23rd starting Johnathon Logue and Michael Johnson, who’d exited to fix a flat tire following an opening-lap skirmish and restarted at the back.Spainhoward had made his first unsuccessful bid to pass following the first restart. McKellar was never able to pull away as cautions kept the field close through midway. Logue was already running fifth when the 15th circuit was scored.One second was the difference between first and second with five laps left. Spainhoward was unable to reel in McKellar and had to settle for a close second.“It’s just unbelievable and I can’t even put this into words. It got a little hairy on that last lap. I got a little loose down the front straightaway and banged the wall,” McKellar said. “This old 2010 car came out here on an open trailer and to come out here and run with these guys is amazing. I’m stoked. It’s the biggest win of my career, for sure.”Bricen James passed D.J. Shannon coming to the white flag and pulled away on the 10th and final circuit to top the Young Guns race for Modified drivers 19 and under. Shannon and Ethan Braaksma completed the top three.Bill Brack led all 10 laps of the Legends feature, repeating his winning way in the Modified race for drivers ages 55 and over. Brack was a couple car lengths ahead of sixth-starting Christy Barnett at the checkers.Feature ResultsModifieds – 1. Terry Phillips, Springfield, Mo.; 2. Eddie Belec, Arvada, Colo.; 3. Peyton Taylor, Batesville, Ark.; 4. Johnny Scott, Cameron, Mo.; 5. Cody Laney, Torrance, Calif.; 6. Ricky Thornton Jr., Chandler, Ariz.; 7. Dominic Ursetta, Arvada, Colo.; 8. Justin O’Brien, West Union, Iowa; 9. Rob Sanders, Bakersfield, Calif.; 10. Ricky Alvarado, Delta, Colo.; 11. Jason Noll, Peoria, Ariz.; 12. Jared Hoefelman, Humphrey, Neb.; 13. Collen Winebarger, Corbett, Ore.; 14. Tim Ward, Chandler, Ariz.; 15. Jason Wolla, Ray, N.D.; 16. Jordan Grabouski, Beatrice, Neb.; 17. Rodney Sanders, Worthington, Minn.; 18. Nick DeCarlo, Martinez, Calif.; 19. John Hansen, Brush, Colo.; 20. Bob Moore, Sioux City, Iowa; 21. Josh Most, Red Oak, Iowa; 22. Scott Drake, Diamond, Mo.; 23. Lucas Schott, Chatfield, Minn.; 24. Jeremy Payne, Buckeye, Ariz.; 25. Casey Skyberg, Rapid City, S.D.; 26. Johnny Saathoff, Beatrice, Neb.; 27. Benji LaCrosse, Green Bay, Wis.; 28. R.C. Whitwell, Tucson, Ariz.Young Guns – 1. Bricen James, Albany, Ore.; 2. D.J. Shannon, Merced, Calif.; 3. Ethan Braaksma, Newton, Iowa; 4. Austin Kuehl, Cave Creek, Ariz.; 5. Dylan Thornton, Santa Maria, Calif.; 6. Brylon Holder, Bakersfield, Calif.; 7. Bubba Stafford Jr., Desert Hills, Ariz.; 8. Braxton Yeager, Green River, Wyo.; 9. Sean Stacy, Kearny, Ariz.; 10. Shane DeVolder, Pacifica, Calif.; 11. Camron Spangler, Dove Creek, Colo.; 13. Troy Morris III, Bakersfield, Calif.; 14. Vinny Raucci, Las Vegas; 15. Matt Belcher, Pahrump; 16. Matthew Mayo, Bakersfield, Calif.; 17. Kendra Vollmer, Idaho Falls, Idaho.Legends – 1. Bill Brack, Mead, Colo.; 2. Christy Barnett. El Paso, Texas; 3. Lawrence O’Connor, Port Hardy, B.C.; 4. Roy Spielman, Mills, Wyo.; 5. Jerry Bailey, Pocatello, Idaho; 6. Jerry Frydrych, Austin, Texas; 7. Steve Streeter, Madera, Calif.Northern SportMods – 1. Chris McKellar, Bakersfield, Calif.; 2. Nick Spainhoward, Bakersfield, Calif.; 3. Robert Elliott, Clinton, Okla.; 4. Johnathon Logue, Boone, Iowa; 5. Michael Johnson, Bakersfield, Calif.; 6. Jason Nation, Bakersfield, Calif.; 7. Shawn Harker, Nebraska City, Neb.; 8. Ethan Braaksma, Newton, Iowa; 9. Fred Ryland, Brentwood, Calif.; 10. Shane DeVolder, Pacifica, Calif.; 11. Arie Schouten, Blair, Neb.; 12. Jason George, Laveen, Ariz.; 13. Luke Krogh, Dickinson, N.D.; 14. Cory Hemphill, Yuma, Ariz.; 15. Gary Dutton, Bakersfield, Calif.; 16. Kyle Wood, Bakersfield, Calif.; 17. Danny Concelman, Colorado Springs, Colo.; 18. Chase Alves, Chandler, Ariz.; 19. Matthew Andrews, Malcolm, Neb.; 20. Jake Sachau, Denison, Iowa; 21. Lee Jensen, Bakersfield, Calif.; 22. Austin Kiefer, Pahrump; 23. Mike Tanner, Smithville, Mo.; 24. Chase Rudolf, Prole, Iowa. Terry Phillips raced to a career fourth IMCA Modified victory Saturday at Las Vegas Motor Speedway’s 20th annual Duel In The Desert. (Photo by Tom Macht, www.photofinishphotos.com)
The FA announced on Tuesday afternoon on its official website that Holloway had been charged over two separate matters. A statement on www.thefa.com said: “Firstly, it is alleged that Holloway’s language and/or behaviour in or around the match officials’ changing room at the end of the game amounted to improper conduct. ”It’s going to be a long hard season for me with these people (referees). I had this with Blackpool. ”Certain clubs get fouls and others don’t. Tottenham will feel that if they play Man United. ”Do I think I would have got that at Tottenham? No I don’t. I just want a bit of fairness. ”I want a foul like anyone else would have got one. I’ve got a horrible taste in my mouth after that.” Holloway then lashed out at the assistant again in his post-match press conference, which began an hour and a half after the end of the match. ”It’s not the referee’s fault, it’s the bloke who stood right where I was, the linesman,” Holloway said. ”We have got professional refs, we haven’t got professional linesmen. ”I can’t believe he didn’t see it. I had better learn what a foul is in this division.” Crystal Palace manager Ian Holloway has been charged by the Football Association in relation to his conduct after the Barclays Premier League match against Tottenham on Sunday. “Secondly, it is alleged that Holloway’s post-match media comments questioned the integrity of the referee and/or match officials and/or implied that the referee and/or match officials were motivated by bias, and/or brought the game into disrepute.” Holloway has until 4pm on Friday to respond to both charges. The game at Selhurst Park, Palace’s first top-flight appearance in eight years, ended in a 1-0 defeat thanks to Roberto Soldado’s second-half penalty. And following the contest, Holloway appeared to claim his team will not be fairly treated by referees this season. He thought the spot-kick should not have been given because he felt Dean Moxey had no time to pull back his left arm to prevent Aaron Lennon’s cross from hitting it. But his real anger was reserved for the officials’ failure to spot what he viewed as a deliberate foul by Nacer Chadli on Stephen Dobbie shortly before referee Mark Clattenburg awarded the penalty. ”I’ve got to learn what a foul is because I thought Nacer Chadli deliberately bodychecked Stephen Dobbie, smashed him down and ran off with the ball,” Holloway told the BBC. ”If the referee didn’t see that, the assistant should have. You have to ask if he’s good enough if he didn’t see that. I don’t see how he can miss it. Press Association
Press Association Saturday’s 1-0 Barclays Premier League defeat by West Brom was the club’s third in succession, in a run of conceding nine goals in three games, and Neil plans to experiment with his starting XI in his attempts to improve the Canaries’ disappointing recent form. Striker Dieumerci Mbokani remains a doubt, owing to illness, but midfielder Youssouf Mulumbu is among those expected to return. “I don’t think it will be wholesale changes,” said Neil, 34. “There’ll be a few. I’ll give guys an opportunity who have trained well and deserve a chance. “You have to make sure the guys are not thrown together, you have to give them an opportunity. At the weekend (defender) Ryan Bennett came in after not featuring so there are definitely places up for grabs. That is not a secret and the squad are fully aware of that. “Results haven’t been as good as we would expect so some of the other lads will get an opportunity and we’ll see what happens from there. “Dieumerci Mbokani has picked up a little bug, flu-type thing, so he has to shake that off but other than that the rest of the squad is fine. Potentially that could rule him out but we’ll see how he recovers from it. “(Youssouf Mulumbu) comes into my thoughts for Everton, along with the rest of the first-team squad. There are guys we need to get minutes because they might be required. “The league is our bread and butter. That is the most important thing for us this year. We want to do well in the cup but if you are prioritising then the league is most important. “I have got to have one eye on that (Saturday’s visit to Manchester City). We’ll give it our all but I need to balance it off to make sure we are fresh. “Not for a second is it a case I could do without this fixture because I can give players a game. The lads not playing are just as important to me as the ones who are because you never know in a week or two they might be the ones called upon, so it is crucial.” Norwich are to give opportunities to several fringe players in Tuesday evening’s Capital One Cup fourth-round fixture at Everton, manager Alex Neil has revealed.