‘Europa League can deliver very good season for Arsenal’

first_imgUnai Emery has been urged to take the Europa League seriously, with Ray Parlour of the opinion that success in that competition can deliver “a very good season” for Arsenal.The Gunners are having to contend with a second successive campaign outside of the Champions League, with Arsene Wenger overseeing a tumble out of the Premier League’s top four.Europe’s second tier competition has not always been a priority for those involved, with Thursday night football often viewed as a hindrance to domestic efforts. Article continues below Editors’ Picks Man Utd ready to spend big on Sancho and Haaland in January Who is Marcus Thuram? Lilian’s son who is top of the Bundesliga with Borussia Monchengladbach Brazil, beware! Messi and Argentina out for revenge after Copa controversy Best player in MLS? Zlatan wasn’t even the best player in LA! Arsenal did, however, make the semi-final stage in 2017-18 and Parlour believes landing major silverware under a boss with a proven track record in the tournament can get the club heading in the right direction once more.He told the Daily Star: “I think the Europa League could be important.“That’s the ideal competition to win because you win a trophy, which a lot of clubs are still waiting for their first trophy, but if you can win the Europa League you’re back in the Champions League as well so that becomes a very good season for any club.“That’s why I was so disappointed last season because they had a great opportunity, especially the first game against Atletico Madrid when they had a man sent off. If you win the game 1-0 or 2-0 you probably go through to the final and maybe win the final.”Arsenal should be able to ease their way into the Europa League knockout stage, with Parlour aware that Emery will only make a decision on how hard to push in continental competition once the Premier League picture becomes clearer in 2019.Arsenal celebrating Arsenal Milan UEFA Europa League 03152018The former Gunners midfielder added: “The one thing about the first few rounds you can rotate your squad, play your different players because it’s not strong obviously.“When the third-place teams come in from the Champions League there are some great clubs coming into the Europa League then.“The great thing about it is you can assess your situation should you qualify for the next stages. Whether it starts February, March you can have a look at it then and say, ‘Where are we in the league?’“If we’ve got no chance of getting in the top four, being realistic we have to concentrate on the Europa League so I think we’ll look at it then.“Maybe he’s fourth in the league and he’s thinking we’ve got to keep this going in the league and that’s when he’ll assess it.“Injuries, suspensions, all these factors come into it.“You don’t abandon anything at the start of the season, you always say, ‘Right hopefully we can challenge.’”last_img read more

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first_imgMARKET RASEN RACING: FREE BET OFFERCheck out details of our FREE BET OFFER offer on the seven Star Sports sponsored races at Market Rasen today.1:45 Download The Star Sports App Now! Mares’ Novices’ Hurdle2:25 First For Cheltenham Specials starsports.bet Handicap Hurdle3:05 Download The Star Sports App Now! Handicap Chase3:45 Davy Russell Festival Blog At starsportsbet.co.uk Conditional Jockeys’ Handicap Hurdle4:25 Download The Star Sports App Now! Handicap Hurdle5:05 Call Star Sports On 08000 521 321 Handicap Chase5:40 Follow Us On Twitter At starsports_bet Standard Open NH Flat RaceBack the winner with an SP of 4/1+ in any of the above seven races and get a free bet to the same stake (win part only) of up to £25 to use on any event later that day. (Full terms below)TERMS AND CONDITIONS(1) Place a bet on any selection in any of the seven Star Sports sponsored races on Thursday (detailed above) and if it wins at an SP of 4/1 or more, we will give you a free bet to the same stake of up to £25 (win part only).(2) Offer open to new and existing customers.(3) Free Bet will be credited as soon as possible after weigh in.(4) Free Bet will expire at midnight on day of reward.FREE BET:GENERAL TERMS AND CONDITIONS(1) Star Sports may offer you a free promotional bet. Please refer to promotion details for the qualification criteria.(2) Any Free Bet is limited to one per person, per promotion, per account, per race. In addition only one Free Bet can be awarded per person, household, shared computer or shared IP address. Free bet applies to your first bet on that race. Where more than one selection in the same race is placed on the same bet slip, the first selection is deemed to be the one which is highest on the bet slip.(3) Free Bets may not be used in conjunction with any other current promotion.(4) In the event of a customer opening more that one account to claim multiple offers we reserve the right to suspend/close duplicate accounts and void any bets placed.(5) Usual Star Sports Betting Rules and Terms and Conditions apply, these can be viewed at starsports.bet.(6) Star Sports reserve the right to withdraw or refuse any Free Bet promotion at any point.(7) Free Bet stakes are not returned with winnings.(8) Free Bet awards cannot be exchanged for cash.(9) Free Bet awards can be used online, tablet or mobile only.(10) The Free Bet must be used within the timeframe specified on the promotion details and may not be either part used or carried forward.(11) If you have any further questions about this promotion you can contact our customer service team [email protected]last_img read more

Greener molecular intermediates may aid drug design

first_img Return to article. Long Description László Kürti Share4Editor’s note: Links to high-resolution images for download appear at the end of this release. David [email protected] [email protected] molecular intermediates may aid drug designRice University scientists further simplify method to make important precursor molecules HOUSTON – (July 5, 2017) – Scientists at Rice University have simplified their approach to synthesize a highly versatile family of precursors en route to biologically active compounds. Their method should make drug design and development cheaper and more environmentally friendly.Synthetic chemist László Kürti and postdoctoral researchers Zhiwei Ma and Zhe Zhou reported their synthesis of unprotected aziridine molecules, key building blocks in synthetic chemistry. The lab’s primary focus is to cut the number of steps it takes to synthesize nitrogen-containing chemical compounds. One way to do so is to simplify the synthesis of precursor molecules that can then be easily modified into products.Their work appears in the Angewandte Chemie International Edition. Return to article. Long DescriptionLászló Kürti. Photo by Jeff FitlowAziridines are triangular structures containing two carbon atoms and a nitrogen atom that are interconnected. The energy content of aziridines is high due to the strain in the three-membered ring. This is the key to their usefulness as building blocks, since they can be opened readily when combined with suitable reaction partners, Kürti said.Synthesizing aziridines that can be modified for the preparation of drugs and other industrial purposes usually involves steps to preserve the ability to functionalize their delicate nitrogen atoms, which are important to keep the products biologically active.“The vast majority of research done in aziridine chemistry concerns only the syntheses of various protected aziridines, which often cannot be further functionalized,” Zhou said. “This simple method gives access to unprotected aziridines, which are much easier to functionalize.”What’s the difference between protected and unprotected aziridines? “The key is the nitrogen atom,” he said. “When this nitrogen is connected to an electron-withdrawing group, the aziridine is protected, while connection to a hydrogen atom or alkyl groups gives rise to unprotected aziridines.”The new method builds upon one introduced three years ago by Kürti and his colleagues and reported in Science. That paper described a way to make aziridines directly from olefin compounds in a single step and under mild conditions, but the transformation in some cases took days and left behind a toxic byproduct. (Olefins consist only of hydrogen and carbon atoms and are produced in huge quantities by the petroleum industry via the cracking of hydrocarbons.)The new work streamlines the process and eliminates the toxicity, Kürti said. “We bring in a really cheap and readily available reagent, hydroxylamine O-sulfonic acid, and utilize it as an electrophilic nitrogen source for olefin aziridination reactions,” he said.The advantages of the one-pot process include the ability to produce aziridines at room temperature in as little as a few hours and with a small amount of catalyst, he said. The only byproduct of the process is an environmentally benign and water-soluble sulfate.The resulting molecules are also stereospecific, Zhou said. “Stereospecificity means that if one takes an olefin into a reaction with a strictly defined double-bond geometry (cis- or trans), that geometry will be fully preserved at the end of the process.”Rice University, the National Institutes of Health, the National Science Foundation and the Robert A. Welch Foundation supported the research.-30-Read the abstract at http://onlinelibrary.wiley.com/doi/10.1002/anie.201705530/fullFollow Rice News and Media Relations via Twitter @RiceUNewsRelated materials:Chemists make strides to simplify drug design and synthesis: http://news.rice.edu/2016/09/12/chemists-make-strides-to-simplify-drug-design-and-synthesis/Kürti Research Group: http://kurtilabs.comImages for download: László Kürti http://news.rice.edu/files/2017/07/0610_LASZLO-1-WEB-2juq5gz.jpgLászló Kürti (Credit: Jeff Fitlow/Rice University)Located on a 300-acre forested campus in Houston, Rice University is consistently ranked among the nation’s top 20 universities by U.S. News & World Report. Rice has highly respected schools of Architecture, Business, Continuing Studies, Engineering, Humanities, Music, Natural Sciences and Social Sciences and is home to the Baker Institute for Public Policy. With 3,879 undergraduates and 2,861 graduate students, Rice’s undergraduate student-to-faculty ratio is 6-to-1. Its residential college system builds close-knit communities and lifelong friendships, just one reason why Rice is ranked No. 1 for happiest students and for lots of race/class interaction by the Princeton Review. Rice is also rated as a best value among private universities by Kiplinger’s Personal Finance. To read “What they’re saying about Rice,” go to http://tinyurl.com/RiceUniversityoverview. AddThislast_img read more